Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …

The spectrum of cardiorenal and metabolic diseases comprises many disorders, including
obesity, type 2 diabetes (T2D), chronic kidney disease (CKD), atherosclerotic cardiovascular …

Niacin, food intake and cardiovascular effects | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Ferrell et al. 1 recently reported associations between serum levels of the terminal niacin
metabolites N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3 …

The most common form of heart failure is heart failure with preserved ejection fraction
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …

Atherosclerotic cardiovascular disease poses a significant global health issue, with
dyslipidemia standing out as a major risk factor. In recent decades, lipid-lowering therapies …

Nicotinamide adenine dinucleotide provides the critical redox pair, NAD+ and NADH, for
cellular energy metabolism. In addition, NAD+ is the precursor for de novo NADP+ synthesis …

Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC)
patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment …