No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

Neuropsychiatric disorders, which arise from a combination of genetic, epigenetic and
environmental influences, epitomize the challenges faced in understanding the mammalian …

The era of the aging society has arrived, and this is accompanied by an increase in the
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …

Viral vector is the most effective means of gene transfer to modify specific cell type or tissue
and can be manipulated to express therapeutic genes. Several virus types are currently …

Pre-existing immunity to human adenovirus serotype 5 (Ad5) is common in the general
population. Bypassing pre-existing immunity could maximize Ad5 vaccine efficacy …

Gene transfer is an increasingly utilized approach for research and clinical applications
involving the central nervous system (CNS). Vectors for gene transfer can be as simple as …

We describe a method that combines Cre-recombinase knockin mice and viral-mediated
gene transfer to genetically label and functionally manipulate specific neuron types in the …

Optogenetics combines optics and genetics to control neuronal activity with cell-type
specificity and millisecond temporal precision. Its use in model organisms such as rodents …

Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …

The ability of recombinant adeno-associated viral (rAAV) vectors to exhibit minimal
immunogenicity and little to no toxicity or inflammation while eliciting robust, multiyear gene …