The proteasome is an essential part of our immune surveillance mechanisms: by generating
peptides from intracellular antigens it provides peptides that are then'presented'to T cells …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Bone resorption is regulated by the immune system,, where T-cell expression of RANKL
(receptor activator of nuclear factor (NF)-κB ligand), a member of the tumour-necrosis factor …

The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular
pathogens requires an extensive display of antigenic peptides by major histocompatibility …

Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high
mortality rates that are a distinguishing feature of this human pathogen. The highest lethality …

Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a
nonspecific and abundant barrel-shaped complex called the 20S proteasome. Substrates …

Three different proteolytic processes have been shown to be important in the generation of
antigenic peptides displayed on MHC-class I molecules. The great majority of these …

Proteasomes perform the majority of proteolysis that occurs in the cytosol and nucleus of
eukaryotic cells and, thereby, perform crucial roles in cellular regulation and homeostasis …

Eukaryotic cells contain various types of proteasomes. Core 20 S proteasomes (abbreviated
20 S below) have two binding sites for the regulatory particles, PA700 and PA28. PA700–20 …

Over the past decade there has been considerable progress in understanding how MHC
class I-presented peptides are generated. The emerging theme is that the immune system …