The proteasome is an essential part of our immune surveillance mechanisms: by generating
peptides from intracellular antigens it provides peptides that are then'presented'to T cells …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Bone resorption is regulated by the immune system,, where T-cell expression of RANKL
(receptor activator of nuclear factor (NF)-κB ligand), a member of the tumour-necrosis factor …

The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular
pathogens requires an extensive display of antigenic peptides by major histocompatibility …

Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high
mortality rates that are a distinguishing feature of this human pathogen. The highest lethality …

Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a
nonspecific and abundant barrel-shaped complex called the 20S proteasome. Substrates …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Proteasomes perform the majority of proteolysis that occurs in the cytosol and nucleus of
eukaryotic cells and, thereby, perform crucial roles in cellular regulation and homeostasis …

Three different proteolytic processes have been shown to be important in the generation of
antigenic peptides displayed on MHC-class I molecules. The great majority of these …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …