[HTML][HTML] Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses
X Chen, X Pan, W Zhang, H Guo, S Cheng, Q He… - … Pharmaceutica Sinica B, 2020 - Elsevier
Immunotherapy strategies targeting the programmed cell death ligand 1 (PD-
L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved …
L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved …
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
KK Wong - Cellular Oncology, 2020 - Springer
Background Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
Hypomethylating agents and immunotherapy: therapeutic synergism in acute myeloid leukemia and myelodysplastic syndromes
Decitabine and guadecitabine are hypomethylating agents (HMAs) that exert inhibitory
effects against cancer cells. This includes stimulation of anti-tumor immunity in acute …
effects against cancer cells. This includes stimulation of anti-tumor immunity in acute …
Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy
The tumour microenvironment plays an instrumental role in cancer development,
progression and treatment response/resistance. Accumulating evidence is underscoring the …
progression and treatment response/resistance. Accumulating evidence is underscoring the …
Decitabine enhances targeting of AML cells by NY-ESO-1-specific TCR-T cells and promotes the maintenance of effector function and the memory phenotype
S Kang, L Wang, L Xu, R Wang, Q Kang, X Gao, L Yu - Oncogene, 2022 - nature.com
NY-ESO-1 is a well-known cancer-testis antigen (CTA) with re-expression in numerous
cancer types, but its expression is suppressed in myeloid leukemia cells. Patients with acute …
cancer types, but its expression is suppressed in myeloid leukemia cells. Patients with acute …
Epigenetic regulations in autoimmunity and cancer: from basic science to translational medicine
L Hui, Z Ziyue, L Chao, Y Bin, L Aoyu… - European journal of …, 2023 - Wiley Online Library
Epigenetics, as a discipline that aims to explain the differential expression of phenotypes
arising from the same gene sequence and the heritability of epigenetic expression, has …
arising from the same gene sequence and the heritability of epigenetic expression, has …
Extracción de conocimiento útil en biomedicina mediante técnicas de minería de patrones
AM Trasierras Fresco - 2023 - helvia.uco.es
La tarea de deteccion de de caracteristicas comunes y unicas de los pacientes aquejados
por el cancer constituye uno de los principales focos de investigacion en la actualidad cuyo …
por el cancer constituye uno de los principales focos de investigacion en la actualidad cuyo …