Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
The important role of zinc in neurological diseases
Zinc is one of the most abundant metal ions in the central nervous system (CNS), where it
plays a crucial role in both physiological and pathological brain functions. Zinc promotes …
plays a crucial role in both physiological and pathological brain functions. Zinc promotes …
Crystal structure of a heterotetrameric NMDA receptor ion channel
N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
NMDA receptor structures reveal subunit arrangement and pore architecture
Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …
requiring binding of glycine and glutamate in combination with the relief of voltage …
Molecular mechanism of ligand gating and opening of NMDA receptor
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
Molecular basis of NMDA receptor functional diversity
NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …
central nervous system and highly permeable to calcium ions. NMDARs have always …
Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors
NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …