Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
Insulin resistance and cardiovascular disease
CE Kosmas, MD Bousvarou… - Journal of …, 2023 - journals.sagepub.com
Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …
health hazards, especially in today's Western societies. A causal-effect relationship has …
A genomic mutational constraint map using variation in 76,156 human genomes
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders,,–, but …
been widely used to investigate protein-coding genes underlying human disorders,,–, but …
A genome-wide mutational constraint map quantified from variation in 76,156 human genomes
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders, but …
been widely used to investigate protein-coding genes underlying human disorders, but …
Menopausal hormone therapy and women's health: An umbrella review
GQ Zhang, JL Chen, Y Luo, MB Mathur… - PLoS …, 2021 - journals.plos.org
Background There remains uncertainty about the impact of menopausal hormone therapy
(MHT) on women's health. A systematic, comprehensive assessment of the effects on …
(MHT) on women's health. A systematic, comprehensive assessment of the effects on …
A narrative review on plasminogen activator inhibitor-1 and its (patho) physiological role: to target or not to target?
M Sillen, PJ Declerck - International journal of molecular sciences, 2021 - mdpi.com
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …
Cardiovascular system in preeclampsia and beyond
Thilaganathan and Kalafat Cardiovascular System in Preeclampsia and Beyond 523 age of
60 years have an increased risk of preeclampsia. 18, 31 Previous preeclampsia is a risk …
60 years have an increased risk of preeclampsia. 18, 31 Previous preeclampsia is a risk …
Preeclampsia: the relationship between uterine artery blood flow and trophoblast function
A Ridder, V Giorgione, A Khalil… - International journal of …, 2019 - mdpi.com
Maternal uterine artery blood flow is critical to maintaining the intrauterine environment,
permitting normal placental function, and supporting fetal growth. It has long been believed …
permitting normal placental function, and supporting fetal growth. It has long been believed …
Fat cell size: measurement methods, pathophysiological origins, and relationships with metabolic dysregulations
The obesity pandemic increasingly causes morbidity and mortality from type 2 diabetes,
cardiovascular diseases and many other chronic diseases. Fat cell size (FCS) predicts …
cardiovascular diseases and many other chronic diseases. Fat cell size (FCS) predicts …
Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2
diabetes. Although epidemiological studies have shown that NAFLD is associated with …
diabetes. Although epidemiological studies have shown that NAFLD is associated with …