[HTML][HTML] Protein oxidation-Formation mechanisms, detection and relevance as biomarkers in human diseases
Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …
Mass spectrometry methods for measuring protein stability
Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …
comprehensive account of the molecular inventory of the cell. In parallel with developments …
Mass spectrometry techniques in emerging pathogens studies: COVID-19 perspectives
As corona virus disease 2019 (COVID-19) is a rapidly growing public health crisis across the
world, our knowledge of meaningful diagnostic tests and treatment for severe acute …
world, our knowledge of meaningful diagnostic tests and treatment for severe acute …
Integration of mass spectrometry data for structural biology
Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …
proteins and the complexes they form with other macromolecules. There are now several …
Added value of internal fragments for top-down mass spectrometry of intact monoclonal antibodies and antibody–drug conjugates
Monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) are two of the most
important therapeutic drug classes that require extensive characterization, whereas their …
important therapeutic drug classes that require extensive characterization, whereas their …
Seeing the complete picture: proteins in top-down mass spectrometry
Top-down protein mass spectrometry can provide unique insights into protein sequence and
structure, including precise proteoform identification and study of protein–ligand and protein …
structure, including precise proteoform identification and study of protein–ligand and protein …
Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is still
ongoing and dramatically influences our life, the need for recombinant viral proteins for …
ongoing and dramatically influences our life, the need for recombinant viral proteins for …
Progress and challenges in mass spectrometry-based analysis of antibody repertoires
Humoral immunity is divided into the cellular B cell and protein-level antibody responses.
High-throughput sequencing has advanced our understanding of both these fundamental …
High-throughput sequencing has advanced our understanding of both these fundamental …
A perspective toward mass spectrometry-based de novo sequencing of endogenous antibodies
ABSTRACT A key step in therapeutic and endogenous humoral antibody characterization is
identifying the amino acid sequence. So far, this task has been mainly tackled through …
identifying the amino acid sequence. So far, this task has been mainly tackled through …
ClipsMS: an algorithm for analyzing internal fragments resulting from top-down mass spectrometry
C Lantz, MA Zenaidee, B Wei… - Journal of proteome …, 2021 - ACS Publications
Top-down mass spectrometry (TD-MS) of peptides and proteins results in product ions that
can be correlated to polypeptide sequence. Fragments can either be terminal fragments …
can be correlated to polypeptide sequence. Fragments can either be terminal fragments …