Summary The cGAS-STING intracellular DNA-sensing pathway has emerged as a key
element of innate antiviral immunity and a promising therapeutic target. The existence of an …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second
messenger that binds and activates the adaptor protein STING, which leads to interferon …

Introduction Genomic instability, a major driving force of cancer and agerelated diseases,
poses an ominous threat to human health and longevity. Nevertheless, several stringent and …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

The accumulation of DNA in the cytosol serves as a key immunostimulatory signal
associated with infections, cancer and genomic damage,. Cytosolic DNA triggers immune …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

Negative regulation of immune pathways is essential to achieve resolution of immune
responses and to avoid excess inflammation. DNA stimulates type I IFN expression through …