Regulated N-glycosylation controls chaperone function and receptor trafficking
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two
oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N …
oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N …
CCDC134 controls TLR biogenesis through the ER chaperone Gp96
L Bernaleau, M Drobek, F Blank, P Walch… - Journal of Experimental …, 2025 - rupress.org
CCDC134 controls TLR biogenesis through the ER chaperone Gp96 | Journal of Experimental
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Medicine | Rockefeller University Press Skip to Main Content Advertisement Umbrella Alt Text …
The role of Toll-like receptors in the pathogenesis of atopic dermatitis
Toll-like receptors (TLR), the key players of the innate immune system, contribute to the
pathogenesis of atopic dermatitis (AD) through multiple pathways. TLRs play a crucial role in …
pathogenesis of atopic dermatitis (AD) through multiple pathways. TLRs play a crucial role in …
OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation
Protein asparagine (N)-glycosylation, which promotes folding and trafficking of cell surface
receptors such as the EGFR, has not been considered a viable target in oncology due to the …
receptors such as the EGFR, has not been considered a viable target in oncology due to the …
CRISPR in therapeutics and diagnostics: Perspectives from landscape analysis
In this report, we examine the extensive research landscape of CRISPR with an emphasis
on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up …
on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up …