The nuclear spin polarization of the noble gas isotopes 3He and 129Xe can be increased
using optical pum** methods by four to five orders of magnitude. This extraordinary gain …

This article reviews the physics and technology of producing large quantities of highly spin-
polarized He 3 nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) …

RATIONALE AND OBJECTIVES: To improve intra-and interobserver variability and enable
the use of functional magnetic resonance imaging (MRI) for multicenter, multiobserver …

Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …

During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …

Lung imaging has traditionally relied on x‐ray methods, since proton MRI is limited to some
extent by low proton density in the lung parenchyma and static field inhomogeneities in the …

This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this
modality has limited the clinical use to imaging of water protons. With hyperpolarization …

Over the past few decades, pulmonary imaging technologies have advanced from chest
radiography and nuclear medicine methods to high-spatial-resolution or low-dose chest CT …

In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity
of human ventilation imaged with hyperpolarized (HP) 3He MRI were developed for the goal …