We describe an approach for designing high-affinity small molecule–binding proteins poised
for downstream sensing. We use deep learning–generated pseudocycles with repeating …

Designing proteins with tailored structures and functions is a long-standing goal in
bioengineering. Recently, deep learning advances have enabled protein structure …

Dynamic protein structures are crucial for deciphering their diverse biological functions. Two-
dimensional infrared (2DIR) spectroscopy stands as an ideal tool for tracing rapid …

The image depicts an artistic representation of the lift-out and sectioning step with a focused
ion beam (FIB), which is referred to as serial lift-out. A block of vitreously frozen biological …

Designing protein-binding proteins is critical for drug discovery. However, artificial-
intelligence-based design of such proteins is challenging due to the complexity of protein …

Designing ligand-binding proteins, such as enzymes and biosensors, is essential in
bioengineering and protein biology. One critical step in this process involves designing …

De novo protein design has advanced such that many peptide assemblies and protein
structures can be generated predictably and quickly. The drive now is to bring functions to …

Proteins are vital biological macromolecules that execute biological functions and form the
core of synthetic biological systems. The history of de novo protein has evolved from initial …

Designing protein-binding proteins is critical for drug discovery. However, the AI-based
design of such proteins is challenging due to the complexity of ligand-protein interactions …

Protein circuit design is still in its infancy in terms of programmability. DNA nanotechnology,
however, excels at this property and its community has created a myriad of circuits and …