Since its discovery over 100 years ago, insulin has been recognized as a key hormone in
control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and …

Insulin is a peptide well known for its role in regulating glucose metabolism in peripheral
tissues. Emerging evidence from human and animal studies indicate the multifactorial role of …

Dementia is a complex set of disorders affecting normal cognitive function. Recently, several
clinical studies have shown that diabetes, obesity, and components of the metabolic …

Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …

The metabolic syndrome (MetS) and Alzheimer's disease share several pathological
features, including insulin resistance, abnormal protein processing, mitochondrial …

Cognitive dysfunction, one of the major concerns of increased life expectancy, is prevalent in
patients with metabolic disorders. Added to the inflammation in the context of aging …

Background Damage to the cerebral vasculature can lead to vascular contributions to
cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to …

Alterations in myelin, the protective and insulating sheath surrounding axons, affect brain
function, as is evident in demyelinating diseases where the loss of myelin leads to cognitive …

Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical
complication of diabetes. The complex pathology of DACD remains unknown. Here, we …

Abstract Background Metabolic syndrome (Mets) is prevalent in the general population and
has been reported to be an independent risk factor for cognitive impairment. This study …