Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

RB Birge, S Boeltz, S Kumar, J Carlson… - Cell Death & …, 2016 - nature.com
Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves
important roles in physiology by sculpting complex tissues during embryogenesis and by …

Calpain research for drug discovery: challenges and potential

Y Ono, TC Saido, H Sorimachi - Nature Reviews Drug Discovery, 2016 - nature.com
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G0/G1 Arrest followed by Necrotic …

AA Zahir, IS Chauhan, A Bagavan… - Antimicrobial agents …, 2015 - journals.asm.org
The aim of the present study was to synthesize silver (Ag) and titanium dioxide (TiO2)
nanoparticles (NPs) using green synthesis from aqueous leaf extract of Euphorbia prostrata …

Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies

AHE Hassan, K Mahmoud, TN Phan… - European Journal of …, 2023 - Elsevier
Amongst different forms of leishmaniasis, visceral leishmaniasis caused by L. donovani is
highly mortal. Identification of new hit compounds might afford new starting points to develop …

2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro

KA da Franca Rodrigues, CN de Sousa Dias… - European journal of …, 2015 - Elsevier
This study evaluated the effects of 2-amino-thiophene derivatives on the promastigote and
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …

Chemoprevention of Leishmaniasis: In-vitro antiparasitic activity of dibenzalacetone, a synthetic curcumin analog leads to apoptotic cell death in Leishmania donovani

IS Chauhan, GS Rao, J Shankar, LKS Chauhan… - Parasitology …, 2018 - Elsevier
Curcumin is the major phenolic compound found in turmeric, a dry powder of rhizomes and
roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around …

Synthesis and photophysical properties of metal complexes of curcumin dyes: Solvatochromism, acidochromism, and photoactivity

BM de França, SSC Oliveira, LOP Souza, TP Mello… - Dyes and …, 2022 - Elsevier
Curcumin and its dyes have attracted attention due to their environment-sensitivity and
optical properties. However, the free molecule has low photoactivity, which is a limitation for …

Increased ROS generation causes apoptosis-like death: mechanistic insights into the anti-Leishmania activity of a potent ruthenium (II) complex

MS Costa, YG Gonçalves, SC Teixeira… - Journal of inorganic …, 2019 - Elsevier
Some metallodrugs that exhibit interesting biological activity contain transition metals such
as ruthenium, and have been extensively exploited because of their antiparasitic potential …

Computational and experimental approaches manifest the leishmanicidal potential of α-mangostin resourced from Garcinia cowa

N Pyne, R Ray, S Paul - Acta Tropica, 2024 - Elsevier
Owing to the persistent number of parasitic deaths, Visceral leishmaniasis continues to
haunt several economically weaker sections of India. The disease causes over 30,000 …

Leishmanicidal therapy targeted to parasite proteases

P de Almeida Machado, MPD Carneiro… - Life sciences, 2019 - Elsevier
Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …