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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves
important roles in physiology by sculpting complex tissues during embryogenesis and by …
important roles in physiology by sculpting complex tissues during embryogenesis and by …
Calpain research for drug discovery: challenges and potential
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G0/G1 Arrest followed by Necrotic …
AA Zahir, IS Chauhan, A Bagavan… - Antimicrobial agents …, 2015 - journals.asm.org
The aim of the present study was to synthesize silver (Ag) and titanium dioxide (TiO2)
nanoparticles (NPs) using green synthesis from aqueous leaf extract of Euphorbia prostrata …
nanoparticles (NPs) using green synthesis from aqueous leaf extract of Euphorbia prostrata …
Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies
Amongst different forms of leishmaniasis, visceral leishmaniasis caused by L. donovani is
highly mortal. Identification of new hit compounds might afford new starting points to develop …
highly mortal. Identification of new hit compounds might afford new starting points to develop …
2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro
KA da Franca Rodrigues, CN de Sousa Dias… - European journal of …, 2015 - Elsevier
This study evaluated the effects of 2-amino-thiophene derivatives on the promastigote and
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …
Chemoprevention of Leishmaniasis: In-vitro antiparasitic activity of dibenzalacetone, a synthetic curcumin analog leads to apoptotic cell death in Leishmania donovani
IS Chauhan, GS Rao, J Shankar, LKS Chauhan… - Parasitology …, 2018 - Elsevier
Curcumin is the major phenolic compound found in turmeric, a dry powder of rhizomes and
roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around …
roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around …
Synthesis and photophysical properties of metal complexes of curcumin dyes: Solvatochromism, acidochromism, and photoactivity
Curcumin and its dyes have attracted attention due to their environment-sensitivity and
optical properties. However, the free molecule has low photoactivity, which is a limitation for …
optical properties. However, the free molecule has low photoactivity, which is a limitation for …
Increased ROS generation causes apoptosis-like death: mechanistic insights into the anti-Leishmania activity of a potent ruthenium (II) complex
MS Costa, YG Gonçalves, SC Teixeira… - Journal of inorganic …, 2019 - Elsevier
Some metallodrugs that exhibit interesting biological activity contain transition metals such
as ruthenium, and have been extensively exploited because of their antiparasitic potential …
as ruthenium, and have been extensively exploited because of their antiparasitic potential …
Computational and experimental approaches manifest the leishmanicidal potential of α-mangostin resourced from Garcinia cowa
Owing to the persistent number of parasitic deaths, Visceral leishmaniasis continues to
haunt several economically weaker sections of India. The disease causes over 30,000 …
haunt several economically weaker sections of India. The disease causes over 30,000 …
Leishmanicidal therapy targeted to parasite proteases
P de Almeida Machado, MPD Carneiro… - Life sciences, 2019 - Elsevier
Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …
therapy has several disadvantages, which makes the search for new therapeutic targets and …