MMP9: a tough target for targeted therapy for cancer
K Augoff, A Hryniewicz-Jankowska, R Tabola, K Stach - Cancers, 2022 - mdpi.com
Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …
The charming world of the extracellular matrix: a dynamic and protective network of the intestinal wall
The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …
only forms a support structure for resident cells but also interacts closely with them by …
Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities
Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …
world still lacks complementary approaches that would significantly enhance the efficacy of …
Strategies to target ADAM17 in disease: from its discovery to the iRhom revolution
M Calligaris, D Cuffaro, S Bonelli, DP Spanò… - Molecules, 2021 - mdpi.com
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
Selective inhibitors of medium-size S1′ pocket matrix metalloproteinases: a step** stone of future drug discovery
Among various matrix metalloproteinases (MMPs), MMPs having medium-size S1′ pockets
are established as promising biomolecular targets for executing crucial roles in cancer …
are established as promising biomolecular targets for executing crucial roles in cancer …
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective
Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …
targets which have been studied intensively in the past few decades. Although several drugs …
Bioactive materials that promote the homing of endogenous mesenchymal stem cells to improve Wound Healing
Z Jiang, L Chen, L Huang, S Yu, J Lin, M Li… - International Journal …, 2024 - Taylor & Francis
Endogenous stem cell homing refers to the transport of endogenous mesenchymal stem
cells (MSCs) to damaged tissue. The paradigm of using well-designed biomaterials to …
cells (MSCs) to damaged tissue. The paradigm of using well-designed biomaterials to …
Current status and perspectives of protease inhibitors and their combination with nanosized drug delivery systems for targeted cancer therapy
M Rudzińska, C Daglioglu, LV Savvateeva… - Drug design …, 2021 - Taylor & Francis
In cancer treatments, many natural and synthetic products have been examined; among
them, protease inhibitors are promising candidates for anti-cancer agents. Since …
them, protease inhibitors are promising candidates for anti-cancer agents. Since …
The CCN2/CTGF interactome: an approach to understanding the versatility of CCN2/CTGF molecular activities
V Zaykov, B Chaqour - Journal of cell communication and signaling, 2021 - Springer
Abstract Cellular communication network 2 (CCN2), also known as connective tissue growth
factor (CTGF) regulates diverse cellular processes, some at odds with others, including …
factor (CTGF) regulates diverse cellular processes, some at odds with others, including …
[HTML][HTML] Skin malignant melanoma and matrix metalloproteinases: promising links to efficient therapies
Skin malignant melanoma (MM) is one of the most frequent and aggressive neoplasia
worldwide. Its associated high mortality rates are mostly due to its metastases, while …
worldwide. Its associated high mortality rates are mostly due to its metastases, while …