Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …

Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly
generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …