Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be
investigated and analyzed in terms of cancer's predisposition, development and prognosis …

Purpose The aim of our study is to provide a precise quantification for the association
between DNA methyltransferase 3B (DNMT3B) variations (rs2424913 C/T, rs1569686 G/T …

High-grade serous (HGS) ovarian cancer accounts for 90% of all ovarian cancer-related
deaths. However, factors that drive HGS ovarian cancer tumor growth have not been fully …

The neural tube is the primordium of the central nervous system (CNS) in which its
development is not entirely clear. Understanding the cellular and molecular basis of neural …

Published data on the association between DNA methyltransferase (DNMT) 3B− 149C/T
polymorphism and cancer risk remain inconclusive. To derive a more precise estimation for …

Background: Folate is essential for DNA synthesis, repair, and methylation. Polymorphisms
in genes associated with folate metabolism may alter these processes and, consequently …

Numerous studies have explored the association of polymorphisms in the DNA
methyltransferase 3b (DNMT3B) gene with the risk of different types of cancer, but yielded …

Background The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate
metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis …

Background Germline variants in DNA methyltransferase 3B (DNMT3B) may influence
DNMT3B enzymatic activity, which, in turn, may affect cancer aggressiveness by altering …

Aim: Intracranial aneurysm is often asymptomatic until the time of rupture. Elevated
homocysteine is reported in vascular diseases. Identifying early events in homocysteine …