Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Transcription factors regulate gene expression through binding to specific enhancer
sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3) …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …

Metabolic diseases are the most common and rapidly growing health issues worldwide. The
massive population-based human genetics is crucial for the precise prevention and …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Abstract Development of a cell therapy for diabetes would be greatly aided by a renewable
supply of human β-cells. Here we show that pancreatic endoderm derived from human …