▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …

The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …

Results from our previous studies demonstrated that activation of Toll-like receptor 4 (Tlr4),
the lipopolysaccharide (LPS) receptor, is sufficient to induce nuclear factor κB activation and …

Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their therapeutic activities through
inhibition of cyclooxygenase (COX), the enzyme that makes prostaglandins (PGs). They …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Peroxisome proliferator-activated receptors (PPARs) are key players in lipid and glucose
metabolism and are implicated in metabolic disorders predisposing to atherosclerosis, such …

▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …