Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in
hematological malignancies. However, the clinical development of immunotoxins is also …

Recent advances in targeted cancer therapy hold great promise for both research and
clinical applications and push the boundaries in finding new treatments for various currently …

Bacterial AB toxins are secreted key virulence factors that are internalized by target cells
through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol …

Targeted intracellular delivery of therapeutic proteins remains a significant unmet challenge
in biotechnology. A promising approach is to leverage the intrinsic capabilities of bacterial …

Many bacterial toxins exert their cytotoxic effects by enzymatically inactivating one or more
cytosolic targets in host cells. To reach their intracellular targets, these toxins possess …

Background: Targeted cancer therapy can be considered as a new strategy to overcome the
side effects of current cancer treatments. Neuropilin-1 (NRP-1) is a transmembrane …

Bacterial AB toxins are secreted virulence factors that are internalized by target cells through
receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from …

Targeted intracellular delivery of therapeutic peptides and proteins remains an important but
unresolved goal in biotechnology. A promising approach is to engineer bacterial exotoxins …

The ability to generate stable transgenic mammalian cell lines is crucial to the investigation
of gene functions and the production of recombinant proteins. Currently, mammalian cells …

Screening approaches have identified many peptide-based biologics with demonstrable in
vivo efficacy. However, clinical translatability is impeded by outstanding challenges in target …