A century of cholesterol and coronaries: from plaques to genes to statins
JL Goldstein, MS Brown - Cell, 2015 - cell.com
One-fourth of all deaths in industrialized countries result from coronary heart disease. A
century of research has revealed the essential causative agent: cholesterol-carrying low …
century of research has revealed the essential causative agent: cholesterol-carrying low …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
Background Evolocumab, a monoclonal antibody that inhibits proprotein convertase
subtilisin–kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) …
subtilisin–kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) …
Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits
Long-read sequencing (LRS) promises to improve the characterization of structural variants
(SVs). We generated LRS data from 3,622 Icelanders and identified a median of 22,636 SVs …
(SVs). We generated LRS data from 3,622 Icelanders and identified a median of 22,636 SVs …
The agenda for familial hypercholesterolemia: a scientific statement from the American Heart Association
2168 Circulation December 1, 2015 sufficient evidence for health benefit exists to implement
case finding via family history–based screening, cascade screening, or other strategies …
case finding via family history–based screening, cascade screening, or other strategies …
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the …
Abstract Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening
condition characterized by markedly elevated circulating levels of low-density lipoprotein …
condition characterized by markedly elevated circulating levels of low-density lipoprotein …
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled …
Background Heterozygous familial hypercholesterolaemia is characterised by low cellular
uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature …
uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature …
Dyslipidemia in obesity: mechanisms and potential targets
B Klop, JWF Elte, M Castro Cabezas - Nutrients, 2013 - mdpi.com
Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …
the incidence of obesity is rising continuously and therefore, the associated morbidity …
Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial
Background Homozygous familial hypercholesterolaemia is a rare, serious disorder caused
by very low or absent plasma clearance of LDL, substantially raised LDL cholesterol, and …
by very low or absent plasma clearance of LDL, substantially raised LDL cholesterol, and …
Diagnosis and treatment of heterozygous familial hypercholesterolemia
MP McGowan, SH Hosseini Dehkordi… - Journal of the …, 2019 - Am Heart Assoc
Familial hypercholesterolemia (FH) is a common yet underdiagnosed autosomal dominant
disorder that affects% 1 in 220 individuals globally. 1 FH is characterized by lifelong …
disorder that affects% 1 in 220 individuals globally. 1 FH is characterized by lifelong …