Acute-on-chronic liver failure

V Arroyo, R Moreau, R Jalan - New England Journal of Medicine, 2020 - Mass Medical Soc
Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

G Mezzano, A Juanola, A Cardenas, E Mezey… - Gut, 2022 - gut.bmj.com
Background and aims Acute-on-chronic liver failure (ACLF) is characterised by acute
decompensation of cirrhosis associated with organ failures. We systematically evaluated the …

Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS)

LS Belli, C Duvoux, T Artzner, W Bernal, S Conti… - Journal of …, 2021 - Elsevier
Background & Aims Liver transplantation (LT) has been proposed as an effective salvage
therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large …

[HTML][HTML] Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment

G Zaccherini, E Weiss, R Moreau - JHEP reports, 2021 - Elsevier
The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …

Acute-on-chronic liver failure: A distinct clinical syndrome

R Moreau, B Gao, M Papp, R Bañares, PS Kamath - Journal of hepatology, 2021 - Elsevier
There are different operating definitions for acute-on-chronic liver failure (ACLF) in different
geographic regions. Consortia in Western countries have developed definitions that apply to …

Model for end-stage liver disease-sodium underestimates 90-day mortality risk in patients with acute-on-chronic liver failure

R Hernaez, Y Liu, JR Kramer, A Rana, HB El-Serag… - Journal of …, 2020 - Elsevier
Background & Aims It is unclear whether the model for end-stage liver disease-sodium
(MELD-Na) score captures the clinical severity of acute-on-chronic liver failure (ACLF). We …

Effect of the clinical course of acute-on-chronic liver failure prior to liver transplantation on post-transplant survival

V Sundaram, S Kogachi, RJ Wong, CJ Karvellas… - Journal of …, 2020 - Elsevier
Background & Aims Patients with acute-on-chronic liver failure (ACLF) can be listed for liver
transplantation (LT) because LT is the only curative treatment option. We evaluated whether …

Fatty liver disease: diagnosis and stratification

Y Saiman, A Duarte-Rojo… - Annual review of …, 2022 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is a major public health crisis affecting
approximately 25% of the world's population. The spectrum of NAFLD ranges from bland …

Definitions, etiologies and outcomes of acute on chronic liver failure: A systematic review and meta-analysis

A Aggarwal, S Biswas, U Arora, M Vaishnav… - Clinical …, 2024 - Elsevier
Abstract Background and Aims Acute-on-chronic liver failure (ACLF) is a major public health
concern. We aimed to assess the definitions, etiological spectrum, organ failure (OF), and …

Acute-on-chronic liver failure: pathophysiological mechanisms and management

A Khanam, S Kottilil - Frontiers in medicine, 2021 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is a multifaceted condition with poor treatment options
and high short-term mortality. ACLF can develop in patients with or without liver cirrhosis …