G-quadruplexes and their regulatory roles in biology
D Rhodes, HJ Lipps - Nucleic acids research, 2015 - academic.oup.com
Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
G-quadruplex structures in bacteria: biological relevance and potential as an antimicrobial target
ABSTRACT DNA strands consisting of multiple runs of guanines can adopt a noncanonical,
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution
F Wu, K Niu, Y Cui, C Li, M Lyu, Y Ren, Y Chen… - Communications …, 2021 - nature.com
Abstract G-quadruplex (G4) structures have been predicted in the genomes of many
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …
Mechanistic insights into the ligand-induced unfolding of an RNA G-quadruplex
S Haldar, Y Zhang, Y **a, B Islam, S Liu… - Journal of the …, 2022 - ACS Publications
The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter
G-Quadruplexes, noncanonical nucleic acid structures, act as silencers in the promoter
regions of human genes; putative G-quadruplex forming sequences are also present in …
regions of human genes; putative G-quadruplex forming sequences are also present in …
Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription
Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to
suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that …
suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that …
G-quadruplexes: more than just a kink in microbial genomes
G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by
guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the …
guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the …
Small-molecule quadruplex-targeted drug discovery
SA Ohnmacht, S Neidle - Bioorganic & medicinal chemistry letters, 2014 - Elsevier
Repeated guanine tracts in human and other genomes can form higher-order four stranded
structures, termed quadruplexes. In the human genome they have particular prevalence in …
structures, termed quadruplexes. In the human genome they have particular prevalence in …