The physiological functions of human peroxisomes

RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Role of ROS and RNS sources in physiological and pathological conditions

S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Redox signaling by reactive electrophiles and oxidants

S Parvez, MJC Long, JR Poganik, Y Aye - Chemical reviews, 2018 - ACS Publications
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Determinants, maintenance, and function of organellar pH

SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

The peroxisome-mitochondria connection: how and why?

M Fransen, C Lismont, P Walton - International journal of molecular …, 2017 - mdpi.com
Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid
and reactive oxygen species metabolism. In mammals, these organelles have also been …

[HTML][HTML] Role of peroxisomes in ROS/RNS-metabolism: implications for human disease

M Fransen, M Nordgren, B Wang… - Biochimica et Biophysica …, 2012 - Elsevier
Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same
time, these organelles generate reactive oxygen and nitrogen species as byproducts …

Metabolic interplay between peroxisomes and other subcellular organelles including mitochondria and the endoplasmic reticulum

RJA Wanders, HR Waterham… - Frontiers in cell and …, 2016 - frontiersin.org
Peroxisomes are unique subcellular organelles which play an indispensable role in several
key metabolic pathways which include:(1.) etherphospholipid biosynthesis;(2.) fatty acid …

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

ED Yoboue, R Sitia, T Simmen - Cell death & disease, 2018 - nature.com
Many cellular redox reactions housed within mitochondria, peroxisomes and the
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …

Plant peroxisomes: biogenesis and function

J Hu, A Baker, B Bartel, N Linka, RT Mullen… - The Plant …, 2012 - academic.oup.com
Peroxisomes are eukaryotic organelles that are highly dynamic both in morphology and
metabolism. Plant peroxisomes are involved in numerous processes, including primary and …

Peroxisomal hydrogen peroxide metabolism and signaling in health and disease

C Lismont, I Revenco, M Fransen - International Journal of Molecular …, 2019 - mdpi.com
Hydrogen peroxide (H2O2), a non-radical reactive oxygen species generated during many
(patho) physiological conditions, is currently universally recognized as an important …