Biology and therapy of inherited retinal degenerative disease: insights from mouse models
S Veleri, CH Lazar, B Chang… - Disease models & …, 2015 - journals.biologists.com
Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …
major cause of incurable vision loss. Tremendous progress has been made over the last two …
[HTML][HTML] The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …
Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
Members of the heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptor (GPCR) family play key roles in many physiological functions and are extensively …
receptor (GPCR) family play key roles in many physiological functions and are extensively …
Phenoty** and genoty** inherited retinal diseases: Molecular genetics, clinical and imaging features, and therapeutics of macular dystrophies, cone and cone-rod …
Inherited retinal diseases (IRD) are a leading cause of blindness in the working age
population and children. The scope of this review is to familiarise clinicians and scientists …
population and children. The scope of this review is to familiarise clinicians and scientists …
[HTML][HTML] Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
PW Reddien, AL Bermange, KJ Murfitt, JR Jennings… - Developmental cell, 2005 - cell.com
Planarians have been a classic model system for the study of regeneration, tissue
homeostasis, and stem cell biology for over a century, but they have not historically been …
homeostasis, and stem cell biology for over a century, but they have not historically been …
Photoreceptor cilia and retinal ciliopathies
Photoreceptors are sensory neurons designed to convert light stimuli into neurological
responses. This process, called phototransduction, takes place in the outer segments (OS) …
responses. This process, called phototransduction, takes place in the outer segments (OS) …
The role of Gβγ subunits in the organization, assembly, and function of GPCR signaling complexes
The role of Gβγ subunits in cellular signaling has become well established in the past 20
years. Not only do they regulate effectors once thought to be the sole targets of Gα subunits …
years. Not only do they regulate effectors once thought to be the sole targets of Gα subunits …
Psychosis pathways converge via D2High dopamine receptors
The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with …
sensitivity that is common to the many animal models of human psychoses associated with …
Kinetic Scaffolding Mediated by a Phospholipase C–β and Gq Signaling Complex
GL Waldo, TK Ricks, SN Hicks, ML Cheever, T Kawano… - Science, 2010 - science.org
Transmembrane signals initiated by a broad range of extracellular stimuli converge on
nodes that regulate phospholipase C (PLC)–dependent inositol lipid hydrolysis for signal …
nodes that regulate phospholipase C (PLC)–dependent inositol lipid hydrolysis for signal …
The cone dysfunction syndromes
The cone dysfunction syndromes are a heterogeneous group of inherited, predominantly
stationary retinal disorders characterised by reduced central vision and varying degrees of …
stationary retinal disorders characterised by reduced central vision and varying degrees of …