Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update

R Siracusa, RD Paola, S Cuzzocrea… - International journal of …, 2021 - mdpi.com
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Role of the prefrontal cortex in pain processing

WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

L Schmaal, AL van Harmelen, V Chatzi… - Molecular …, 2020 - nature.com
Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are
important to develop more targeted and effective strategies to prevent suicide. In the last …

Neurobiology of fibromyalgia and chronic widespread pain

KA Sluka, DJ Clauw - Neuroscience, 2016 - Elsevier
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

Physical exercise as non-pharmacological treatment of chronic pain: why and when

KR Ambrose, YM Golightly - Best practice & research Clinical rheumatology, 2015 - Elsevier
Chronic pain broadly encompasses both objectively defined conditions and idiopathic
conditions that lack physical findings. Despite variance in origin or pathogenesis, these …

The mesolimbic dopamine system in chronic pain and associated affective comorbidities

RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

Fibromyalgia: a critical and comprehensive review

AT Borchers, ME Gershwin - Clinical reviews in allergy & immunology, 2015 - Springer
Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Interoception in anxiety and depression

MP Paulus, MB Stein - Brain structure and Function, 2010 - Springer
We review the literature on interoception as it relates to depression and anxiety, with a focus
on belief, and alliesthesia. The connection between increased but noisy afferent …

Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula

JA Avery, WC Drevets, SE Moseman, J Bodurka… - Biological …, 2014 - Elsevier
Background Somatic complaints and altered interoceptive awareness are common features
in the clinical presentation of major depressive disorder (MDD). Recently, neurobiological …

The cerebral signature for pain perception and its modulation

I Tracey, PW Mantyh - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …