Seven major cell–cell signaling pathways—Wnt, TGF-ß, Hedgehog (Hh), receptor tyrosine
kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate …

Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

The Drosophila Groucho (Gro) protein is the prototype for a large family of corepressors,
examples of which are found in most metazoans. This family includes the human transducin …

The Drosophila gene groucho (gro) encodes a transcriptional corepressor that has critical
roles in many development processes. In an effort to illuminate the mechanism of Gro …

Gene-specific repression of transcription plays a central role in gene regulation. This is true
for the spatial control of gene activity in development, during which boundaries of gene …

Differentiation of the embryonic termini in Drosophila depends on signaling by the Tor RTK,
which induces terminal gene expression by inactivating at the embryonic poles a uniformly …

Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in
metazoans, often by regulating the expression of downstream genes. In Drosophila …

Extensive analysis during the last 10–15 years has identified many of the mechanisms and
factors involved in the activation of eukaryotic gene transcription. Although activation is …

Pax5 (BSAP) functions as both a transcriptional activator and repressor during midbrain
patterning, B‐cell development and lymphomagenesis. Here we demonstrate that Pax5 …

Sprouty was originally identified as an inhibitor of Drosophila FGF receptor signaling during
tracheal development. By following the capacity of ectopic Sprouty to abolish the pattern of …