The molecular landscape of head and neck cancer
CR Leemans, PJF Snijders, RH Brakenhoff - Nature Reviews Cancer, 2018 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
The changing therapeutic landscape of head and neck cancer
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label …
TY Seiwert, B Burtness, R Mehra, J Weiss… - The lancet …, 2016 - thelancet.com
Background Patients with recurrent or metastatic squamous cell carcinoma of the head and
neck have few treatment options. We aimed to assess the safety, tolerability, and antitumour …
neck have few treatment options. We aimed to assess the safety, tolerability, and antitumour …
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS–ESMO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and …
Squamous cell carcinoma of the head and neck (SCCHN) arises from epithelial cells and
occurs in the oral cavity, pharynx and larynx. Nasopharyngeal carcinoma (NPC) is a disease …
occurs in the oral cavity, pharynx and larynx. Nasopharyngeal carcinoma (NPC) is a disease …
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …
characterized by high morbidity and low survival rates with limited therapeutic options …
Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno …
S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …
implications of this response are increasingly recognized, and as immunotherapies are …
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
[HTML][HTML] Cancer-cell-intrinsic mechanisms sha** the tumor immune landscape
Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …
[HTML][HTML] Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis
Here, we describe a multiplexed immunohistochemical platform with computational image
processing workflows, including image cytometry, enabling simultaneous evaluation of 12 …
processing workflows, including image cytometry, enabling simultaneous evaluation of 12 …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …