Standardization of the rat dorsal random pattern (McFarlane) flap model and evaluation of the pharmacological agents aiming to salvage partial flap necrosis: A …

GG Üstün, S Öztürk, U Koçer - Annals of Plastic Surgery, 2021‏ - journals.lww.com
Materials and Methods PubMed, Scopus, and Web of Science databases were screened for
words “McFarlane flap,”“flap survival,” and (“flap” and “rat”) by using time limits between …

Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism

N Javdan, SA Ayatollahi, MI Choudhary, S Al-Hasani… - Theriogenology, 2018‏ - Elsevier
Scope Testicular torsion and subsequent release of reactive oxygen species (ROS) can
cause infertility in adults. Oxidative stress following testicular torsion plays an important role …

Low-level laser irradiation, cyclooxygenase-2 (COX-2) expression and necrosis of random skin flaps in rats

I Esteves Junior, IB Masson, CTF Oshima… - Lasers in medical …, 2012‏ - Springer
Skin flaps are still a matter of concern among surgeons, as failures can occur leading to flap
necrosis. However, low-level laser irradiation has been reported as an effective tool to …

Experimental rat skin flap model that distinguishes between venous congestion and arterial ischemia: the reverse U-shaped bipedicled superficial inferior epigastric …

NM Matsumoto, M Aoki, J Nakao… - Plastic and …, 2017‏ - journals.lww.com
Background: The commonly used flap models have drawbacks that limit their usefulness. In
the random skin flap model, flap necrosis is caused by both arterial and venous …

Photobiomodulation effect in tumoral necrosis factor-alpha (TNF-α) on the viability of random skin flap in rats

GR Esteves, IE Junior, IFB Masson… - Lasers in Medical …, 2022‏ - Springer
The aim of this study was to investigate the effect of red laser (660 nm) photobiomodulation
(PBM) with different energies on tumor necrosis factor-alpha (TNF-α) expression for random …

BCL-2 and Bax expression in skin flaps treated with finasteride or azelaic acid

SA Ayatollahi, M Ajami, H Reyhanfard… - Iranian Journal of …, 2012‏ - pmc.ncbi.nlm.nih.gov
Despite all modern surgical techniques, skin flap that is considered as the main method in
most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis …

Comparative analysis of the effect of antihypertensive drugs on the survival of perforator flaps in a rat model

JW Park, GH Mun - Microsurgery, 2018‏ - Wiley Online Library
Background First‐line antihypertensive drugs include calcium channel blockers, angiotensin
converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. In this study, we …

Effects of antihypertensive drugs on outcomes of breast reconstruction

JW Park, KT Lee, BJ Jeon, JK Pyon, SI Bang… - Annals of Surgical …, 2019‏ - Springer
Background Angiotensin receptor blocker (ARB), a commonly used antihypertensive drug, is
reported to affect wound healing and flap survival in animal models. However, this has not …

Effects of antihypertensive drugs on surgical outcomes of breast reconstruction: a nationwide population-based claim study

JW Park, HY Park, M Park, M Yang, GH Mun - Gland Surgery, 2021‏ - pmc.ncbi.nlm.nih.gov
Background Experimental studies have reported that angiotensin receptor blockers (ARBs)
increase the risk of surgical complications. However, clinical data on their effect on surgical …

Combination therapy profoundly improved skin flap survival by modulating KATP channels and nitric oxide

M Farrokhi, MZ Gashti, M Hoormand… - Advances in medical …, 2019‏ - Elsevier
Purpose A potential therapeutic approach on skin flap necrosis is to target parallel pathways
involved in necrosis. Azelaic Acid, Minoxidil and Caffeine combination was tried on skin flap …