Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

Fluid–structure interaction is ubiquitous in nature and occurs at all biological scales.
Immersed methods provide mathematical and computational frameworks for modeling fluid …

Finite element analysis (FEA) and computational fluid dynamics (CFD) are generally
insufficient independently to model the physics of the cardiovascular system. Individually …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …

We present a space–time (ST) isogeometric analysis framework for car and tire
aerodynamics with road contact and tire deformation and rotation. The geometries of the …

The superior accuracy isogeometric analysis (IGA) brought to computations in fluid and solid
mechanics has been yielding higher fidelity in computational aerodynamics. The increased …

We present an extensive study on boundary layer mesh resolution in flow computation with
the Space–Time Variational Multiscale (ST-VMS) method and isogeometric discretization …

Valvular heart disease has recently become an increasing public health concern due to the
high prevalence of valve degeneration in aging populations. For patients with severely …

We present method-evaluation incompressible-flow computations with Space–Time
Isogeometric Analysis (ST-IGA) and higher-order basis functions in time. The computational …