Introduction Carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) are
extensively used worldwide due to their antipyretic, analgesic, and anti-inflammatory effects …

Loxoprofen has been widely used as a non-steroidal anti-inflammatory drug globally and it
can also persist in the environment. Although it is known to be a non-toxic drug, its presence …

Hepatotoxicity is a leading cause of attrition in the drug development process. Traditional
preclinical and clinical studies to evaluate hepatotoxicity liabilities are expensive and time …

The white-rot fungus Phanerochaete sordida YK-624 is capable of degrading various
emerging contaminants (ECs), with cytochrome P450 (CYP) enzymes playing crucial …

Abstract Background Caffeine (0.1 g) is used as a central nervous system stimulant and as a
nontoxic phenoty** probe for cytochrome P450 1A2. However, an increasing number of …

We discuss a neural network (NN) approach to predicting the density-functional-theory-
calculated properties of bioactive molecules. This method is guided by lower-level quantum …

Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the
treatment of pain and inflammation caused by chronic and transitory conditions. Its alcoholic …

Lower respiratory tract infections are prevalent in South Korea, and clarithromycin,
amoxicillin, clavulanate, and loxoprofen are frequently prescribed for these infections. In …

Hydrocoptisonine is a new compound that has been isolated from the rhizomes of Coptis
chinensis, which belongs to the Ranunculaceae family of Chinese medicines. Although …

Loxoprofen is a prodrug that exerts strong analgesic and anti‐inflammatory effects through
its active trans‐alcohol metabolite, which is produced in the liver by carbonyl reductase …