Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …

Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …

The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …

Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar
membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its …

The causative agent of malaria, Plasmodium, replicates inside a membrane-bound
parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the …

The coordinated exit of intracellular pathogens from host cells is a process critical to the
success and spread of an infection. While phospholipases have been shown to play …

Protein export is central for the survival and virulence of intracellular P. falciparum blood
stage parasites. To reach the host cell, exported proteins cross the parasite plasma …

Discovery and development of antimalarial drugs have long been dominated by single-
target therapy. Continuous effort has been made to explore and identify different targets in …

Apicomplexan parasites, including the Plasmodium species that cause malaria, contain
three unusual apical secretory organelles (micronemes, rhoptries, and dense granules) that …