HIV-1 has evolved a plethora of strategies to overcome the cytoskeletal barrier (ie, actin and
intermediate filaments (AFs and IFs) and microtubules (MTs)) to achieve the viral cycle. HIV …

Valid, responsive blood biomarkers specific to peripheral nerve damage would improve
management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) …

Neurofilaments are intermediate filaments present in neurons. These provide structural
support and maintain the size and shape of the neurons. Dysregulation, mutation, and …

DNA-based therapeutics have emerged as a revolutionary approach for addressing the
treatment gap in rare inherited conditions by targeting the fundamental genetic causes of …

Background/Objectives: Comorbid post-traumatic stress disorder (PTSD) and alcohol use
disorder (AUD) patients are at a significantly higher risk of adverse outcomes, including …

Traumatic axonal injury (TAI) is one of the most common pathological features of severe
traumatic brain injury (TBI). Our previous study using proteomics suggested that peripherin …

Peripherin belongs to heterogeneous class III of intermediate filaments, and it is the only
intermediate filament protein selectively expressed in the neurons of the peripheral nervous …

The cytoskeleton is an important structural component that regulates various aspects of cell
morphology, movement, and intracellular signaling. It plays a pivotal role in the cellular …

Oncolytic viruses have two anticancer functions: direct oncolysis and elicitation of antitumor
immunity. We previously developed a novel fusogenic oncolytic vaccinia virus (FUVAC) from …

Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is
caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight …