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Mass spectrometry‐based protein–protein interaction networks for the study of human diseases
A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …
expediting the development of novel therapeutic interventions. Disease mechanisms are …
[HTML][HTML] Identification of required host factors for SARS-CoV-2 infection in human cells
To better understand host-virus genetic dependencies and find potential therapeutic targets
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
J Li, M Guo, X Tian, X Wang, X Yang, P Wu, C Liu… - Med, 2021 - cell.com
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health …
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health …
Meta-and orthogonal integration of influenza “OMICs” data defines a role for UBR4 in virus budding
Several systems-level datasets designed to dissect host-pathogen interactions during
influenza A infection have been reported. However, apparent discordance among these …
influenza A infection have been reported. However, apparent discordance among these …
[HTML][HTML] Comparative flavivirus-host protein interaction map** reveals mechanisms of dengue and Zika virus pathogenesis
Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
Dengue virus non-structural protein 5 as a versatile, multi-functional effector in host–pathogen interactions
P Bhatnagar, GP Sreekanth… - Frontiers in Cellular …, 2021 - frontiersin.org
Dengue is emerging as one of the most prevalent mosquito-borne viral diseases of humans.
The 11kb RNA genome of the dengue virus encodes three structural proteins (envelope, pre …
The 11kb RNA genome of the dengue virus encodes three structural proteins (envelope, pre …
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
KM Haas, MJ McGregor, M Bouhaddou… - Nature …, 2023 - nature.com
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
The dengue virus NS5 protein intrudes in the cellular spliceosome and modulates splicing
FA De Maio, G Risso, NG Iglesias, P Shah… - PLoS …, 2016 - journals.plos.org
Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells,
enabling viral RNA replication and counteracting host antiviral responses. Here, we …
enabling viral RNA replication and counteracting host antiviral responses. Here, we …
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but
its exact functions, and the structural basis of those functions, remain unknown. Here, we …
its exact functions, and the structural basis of those functions, remain unknown. Here, we …