Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that
has been thoroughly revised. Don and Judy Voet explain biochemical concepts while …

The plasma membrane is the interface between cells and their harsh environment. Uptake of
nutrients and all communication among cells and between cells and their environment …

Molecular replacement (MR) generally becomes more difficult as the number of components
in the asymmetric unit requiring separate MR models (ie the dimensionality of the search) …

▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …

Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …