The emerging role of the piRNA/piwi complex in cancer

Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

H Khanbabaei, S Ebrahimi… - Journal of Experimental …, 2022 - Springer
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic
development during which epithelial cells acquire mesenchymal characteristics, and the …

piRBase: a comprehensive database of piRNA sequences

J Wang, P Zhang, Y Lu, Y Li, Y Zheng… - Nucleic acids …, 2019 - academic.oup.com
PIWI-interacting RNAs are a class of small RNAs that is most abundantly expressed in
animal germline. Substantial research is going on to reveal the functions of piRNAs in the …

piRBase: integrating piRNA annotation in all aspects

J Wang, Y Shi, H Zhou, P Zhang, T Song… - Nucleic acids …, 2022 - academic.oup.com
Piwi-interacting RNAs are a type of small noncoding RNA that have various functions.
piRBase is a manually curated resource focused on assisting piRNA functional analysis …

The biogenesis and functions of piRNAs in human diseases

X Wu, Y Pan, Y Fang, J Zhang, M **e, F Yang… - … Therapy Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …

Piwi-interacting RNAs in cancer: emerging functions and clinical utility

KW Ng, C Anderson, EA Marshall, BC Minatel… - Molecular cancer, 2016 - Springer
PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally
described in the germline, there are over 20,000 piRNA genes in the human genome. In …

PIWI proteins and PIWI-interacting RNA: emerging roles in cancer

YN Han, Y Li, SQ **a, YY Zhang, JH Zheng… - Cellular Physiology and …, 2018 - karger.com
P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

H Yan, QL Wu, CY Sun, LS Ai, J Deng, L Zhang… - Leukemia, 2015 - nature.com
Aberrant DNA hypermethylation contributes to myelomagenesis by silencing tumor-
suppressor genes. Recently, a few reports have suggested that a novel class of small non …

The regulatory function of piRNA/PIWI complex in cancer and other human diseases: The role of DNA methylation

DD Jia, H Jiang, YF Zhang, Y Zhang… - … journal of biological …, 2022 - pmc.ncbi.nlm.nih.gov
Piwi-interacting RNAs (piRNAs) are a class of short chain noncoding RNAs that are
constituted by 26-30 nucleotides (nt) and can couple with PIWI protein family. piRNAs were …

The biogenesis and biological function of PIWI-interacting RNA in cancer

S Chen, S Ben, J **n, S Li, R Zheng, H Wang… - Journal of hematology & …, 2021 - Springer
Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant
levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI …