The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …

The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described:
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …

Intrinsically disordered proteins and regions carry out varied and vital cellular functions.
Proteins with disordered regions are especially common in eukaryotic cells, with a subset of …

Micro-vesicles can be released by different cell types and operate as 'safe containers'
mediating inter-cellular communication. In this work we investigated whether cultured …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

In the past few years there has been a growing awareness that a large number of proteins
contain long disordered (unstructured) regions that often play a functional role. However …

The finding that a large fraction of proteins (over 30%) in eukaryotic cells lack a unique three-
dimensional structure but are functional has forced the scientific community to review its …

In the last 2 decades it has become increasingly evident that a large number of proteins are
either fully or partially disordered. Intrinsically disordered proteins lack a stable 3D structure …

An Internet server at http://bip. weizmann. ac. il/dipol calculates the net charge, dipole
moment and mean radius of any 3D protein structure or its constituent peptide chains, and …