Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …
the central nervous system (CNS); however, residual glutamate in the extracellular space is …
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …
which initiates rapid signal transmission in the synapse before its re-uptake into the …
Glutamate uptake
NC Danbolt - Progress in neurobiology, 2001 - Elsevier
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …
glutamate transporter proteins present in the plasma membranes of both glial cells and …
Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to …
GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …
The regulation of astrocytic glutamate transporters in health and neurodegenerative diseases
The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …
Role of excitatory amino acid transporter‐2 (EAAT2) and glutamate in neurodegeneration: opportunities for develo** novel therapeutics
Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
AL Sheldon, MB Robinson - Neurochemistry international, 2007 - Elsevier
Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …
related excitatory amino acids are maintained at relatively low levels to ensure an …
Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …
NF-κB in the nervous system
B Kaltschmidt, C Kaltschmidt - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
The transcription factor NF-κB has diverse functions in the nervous system, depending on
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …
Excitatory amino acid transporters in physiology and disorders of the central nervous system
AR Malik, TE Willnow - International journal of molecular sciences, 2019 - mdpi.com
Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …