Heat shock proteins are molecular chaperones which support tumor development by
regulating various cellular processes including unfolded protein response, mitochondrial …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

The abnormal upregulation of programmed death ligand-1 (PD-L1) on tumor cells impedes
T-cell mediated cytotoxicity through PD-1 engagement, and further exploring the …

Anthracyclines are a class of conventionally and routinely used first-line chemotherapy
drugs for cancer treatment. In addition to the direct cytotoxic effects, increasing evidence …

Although the role of microtubule dynamics in cancer progression is well-established, the
roles of tubulin isotypes, their cargos and their specific function in the induction and …

Homeobox (HOX) transcript antisense RNA (Hotair) is elevated in many cancers
significantly. However, the oncogenic role of Hotair in human laryngeal squamous cell …

Pin1, a peptide prolyl cis-trans isomerase, is overexpressed and/or overactivated in many
human malignancies. However, whether Pin1 regulates the immunosuppressive TME has …

Abstract GRP78 (Glucose-related protein 78, BiP/HSPA5) is commonly overexpressed in
cancer cells. Acting as an activator of endoplasmic reticulum stress, GRP78 is involved in …

Breast cancer (BC) is not only a mass of malignant cells but also a systemic inflammatory
disease. BC pro-tumorigenic inflammation has been shown to promote immune evasion and …

Background The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer
cells inhibits T cell-mediated cytotoxicity, but the molecular mechanisms that drive and …