The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Towards a systems understanding of MHC class I and MHC class II antigen presentation
J Neefjes, MLM Jongsma, P Paul… - Nature reviews …, 2011 - nature.com
The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …
molecules have been studied extensively for almost three decades. Although the basic …
HIV and HLA class I: an evolving relationship
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
Selection bias at the heterosexual HIV-1 transmission bottleneck
Introduction Heterosexual HIV-1 transmission is an inefficient process with rates reported at<
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …
Africa-specific human genetic variation near CHD1L associates with HIV-1 load
PJ McLaren, I Porreca, G Iaconis, HP Mok… - Nature, 2023 - nature.com
HIV-1 remains a global health crisis, highlighting the need to identify new targets for
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration
L Azzoni, AS Foulkes, E Papasavvas… - The Journal of …, 2013 - academic.oup.com
Abstract Background. Antiretroviral therapy (ART)–mediated immune reconstitution fails to
restore the capacity of the immune system to spontaneously control human …
restore the capacity of the immune system to spontaneously control human …
Vertical T cell immunodominance and epitope entropy determine HIV-1 escape
HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and
killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide …
killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide …
Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression
K Poropatich, DJ Sullivan Jr - Journal of General Virology, 2011 - microbiologyresearch.org
A small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive
individuals–referred to as long-term non-progressors (LTNPs)–maintain a favourable course …
individuals–referred to as long-term non-progressors (LTNPs)–maintain a favourable course …
Human-leukocyte antigen class I Cw 1502 and class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection
One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were
recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human …
recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human …
Definition of the viral targets of protective HIV-1-specific T cell responses
Background The efficacy of the CTL component of a future HIV-1 vaccine will depend on the
induction of responses with the most potent antiviral activity and broad HLA class I …
induction of responses with the most potent antiviral activity and broad HLA class I …