The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Cell–cell and cell–extracellular-matrix (cell–ECM) adhesions have much in common,
including shared cytoskeletal linkages, signaling molecules and adaptor proteins that serve …

Abstract The small GTPase Ran, bound to GTP, is required for the induction of spindle
formation by chromosomes in M phase. High concentrations of Ran. GTP are proposed to …

The protein PCM-1 localizes to cytoplasmic granules known as “centriolar satellites” that are
partly enriched around the centrosome. We inhibited PCM-1 function using a variety of …

Aberrations in centrosome numbers have long been implicated in aneuploidy and
tumorigenesis, but their origins are unknown. Here we have examined how overexpression …

Background: In cells lacking centrosomes, the microtubule-organizing activity of the
centrosome is substituted for by the combined action of chromatin and molecular motors …