Current controversies in medical cannabis: Recent developments in human clinical applications and potential therapeutics

AK Schlag, SE O'Sullivan, RR Zafar, DJ Nutt - Neuropharmacology, 2021 - Elsevier
Abstract Knowledge about the therapeutic potential of medical cannabis has greatly
improved over the past decade, with an ever-increasing range of developments in human …

Opportunities, challenges and pitfalls of using cannabidiol as an adjuvant drug in COVID-19

B Malinowska, M Baranowska-Kuczko… - International journal of …, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to
coronavirus disease 2019 (COVID-19) which, in turn, may be associated with multiple organ …

Efficacy and safety of cannabidiol plus standard care vs standard care alone for the treatment of emotional exhaustion and burnout among frontline health care …

JAS Crippa, AW Zuardi, FS Guimarães… - JAMA network …, 2021 - jamanetwork.com
Importance Frontline health care professionals who work with patients with COVID-19 have
an increased incidence of burnout symptoms. Cannabidiol (CBD) has anxiolytic and …

Cannabidiol inhibits SARS‐Cov‐2 spike (S) protein‐induced cytotoxicity and inflammation through a PPARγ‐dependent TLR4/NLRP3/Caspase‐1 signaling …

C Corpetti, A Del Re, L Seguella, I Palenca… - Phytotherapy …, 2021 - Wiley Online Library
Given the abundancy of angiotensin converting enzyme 2 (ACE‐2) receptors density,
beyond the lung, the intestine is considered as an alternative site of infection and replication …

β-Caryophyllene, a natural dietary CB2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in Covid-19

NK Jha, C Sharma, HM Hashiesh… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health …

Cannabidiol for COVID-19 patients with mild to moderate symptoms (CANDIDATE Study): a randomized, double-blind, placebo-controlled clinical trial

JAS Crippa, JC Pacheco, AW Zuardi… - Cannabis and …, 2022 - liebertpub.com
Importance: Owing to its anti-inflammatory properties and antiviral “in vitro” effect against
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cannabidiol (CBD) has …

An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects

N Martinez Naya, J Kelly, G Corna, M Golino… - Molecules, 2024 - mdpi.com
Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has
garnered increasing attention for its diverse therapeutic potential. This comprehensive …

The immunopathology of COVID-19 and the cannabis paradigm

N Paland, A Pechkovsky, M Aswad, H Hamza… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-19 caused by the novel RNA betacoronavirus SARS-CoV2 has first
emerged in Wuhan, China in December 2019, and since then developed into a worldwide …

Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review

MS Mahmud, MS Hossain, ATMF Ahmed, MZ Islam… - Molecules, 2021 - mdpi.com
Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug
discovery is a paramount need. Cannabis sativa contains hundreds of chemical constituents …

[HTML][HTML] Recombinant human DNase-I improves acute respiratory distress syndrome via neutrophil extracellular trap degradation

A Jarrahi, H Khodadadi, NS Moore, Y Lu… - Journal of Thrombosis …, 2023 - Elsevier
Background Respiratory failure is the primary cause of death in patients with COVID-19,
whereas coagulopathy is associated with excessive inflammation and multiorgan failure …