Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022‏ - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021‏ - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Polycystic ovary syndrome

E Stener-Victorin, H Teede, RJ Norman… - Nature Reviews …, 2024‏ - nature.com
Abstract Despite affecting~ 11–13% of women globally, polycystic ovary syndrome (PCOS)
is a substantially understudied condition. PCOS, possibly extending to men's health …

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

F Day, T Karaderi, MR Jones, C Meun, C He… - PLoS …, 2018‏ - journals.plos.org
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …

Resistance to the insulin and elevated level of androgen: A major cause of polycystic ovary syndrome

H Ding, J Zhang, F Zhang, S Zhang, X Chen… - Frontiers in …, 2021‏ - frontiersin.org
PCOS has a wide range of negative impacts on women's health and is one of the most
frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and …

Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome

J Wang, D Wu, H Guo, M Li - Life sciences, 2019‏ - Elsevier
Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive
endocrine diseases, which has a variety of effects on a woman's health. Because of the …

Polycystic ovary syndrome

R Azziz, E Carmina, ZJ Chen, A Dunaif… - Nature reviews Disease …, 2016‏ - nature.com
Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide.
The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic …

Adipose tissue dysfunction in polycystic ovary syndrome

F Bril, U Ezeh, M Amiri, S Hatoum… - The Journal of …, 2024‏ - academic.oup.com
Purpose Polycystic ovary syndrome (PCOS) is a complex genetic trait and the most common
endocrine disorder of women, clinically evident in 5% to 15% of reproductive-aged women …

Hyperandrogenic origins of polycystic ovary syndrome–implications for pathophysiology and therapy

DH Abbott, DA Dumesic, JE Levine - Expert review of …, 2019‏ - Taylor & Francis
Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of
female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial …

New insights into the genetics of polycystic ovary syndrome

R Azziz - Nature Reviews Endocrinology, 2016‏ - nature.com
© 2016 Macmillan Publishers Limited. All rights reserved sex-hormone-binding globulin.
Furthermore, genetic susceptibility to later menopause was associated with an increased …