Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

Posttranslational modifications of histones (PTMs) are associated with specific chromatin
and gene expression states,. Although studies in Drosophila melanogaster have revealed …

Chromatin features are widely used for genome-scale map** of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

H3K27ac is well recognized as a marker for active enhancers and a great indicator of
enhancer activity. However, its functional impact on transcription has not been …

The past three decades have yielded a wealth of information regarding the chromatin
regulatory mechanisms that control transcription. The “histone code” hypothesis—which …

Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …

Histone modifications are associated with distinct transcriptional states, but it is unclear
whether they instruct gene expression. To investigate this, we mutate histone H3. 3 K9 and …

Precise spatiotemporal regulation of gene expression is of paramount importance for
eukaryotic development. The maternal-to-zygotic transition (MZT) during early …