UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …

UV-radiations are the invisible part of light spectra having a wavelength between visible rays
and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320–400 nm), UV-B …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

Abstract The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial
role in human and mouse pigmentation,,,,,,,. Activation of MC1R in melanocytes by α …

Abstract Melanocortin‐1‐receptor (MC1R) is one of the major genes that determine skin
pigmentation. MC1R variants were suggested to be associated with red hair, fair skin, and …

We present results from a genome-wide association study for variants associated with
human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in …

The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Fair color increases risk of cutaneous melanoma (CM) and basal cell carcinoma (BCC).
Recent genome-wide association studies have identified variants affecting hair, eye and …