Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association

R Ross, SN Blair, R Arena, TS Church, JP Després… - Circulation, 2016 - Am Heart Assoc
Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF)
are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality …

Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis

JM Northey, N Cherbuin, KL Pumpa… - British journal of sports …, 2018 - bjsm.bmj.com
Background Physical exercise is seen as a promising intervention to prevent or delay
cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is …

Exercise benefits on Alzheimer's disease: State-of-the-science

PL Valenzuela, A Castillo-García, JS Morales… - Ageing research …, 2020 - Elsevier
Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …

A review of the effects of physical activity and exercise on cognitive and brain functions in older adults

L Bherer, KI Erickson… - Journal of aging research, 2013 - Wiley Online Library
Studies supporting the notion that physical activity and exercise can help alleviate the
negative impact of age on the body and the mind abound. This literature review provides an …

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

JK Morris, ED Vidoni, DK Johnson, A Van Sciver… - PloS one, 2017 - journals.plos.org
Background There is increasing interest in the role of physical exercise as a therapeutic
strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 …

Physical exercise and cognitive performance in the elderly: current perspectives

NJ Kirk-Sanchez, EL McGough - Clinical interventions in aging, 2014 - Taylor & Francis
In an aging population with increasing incidence of dementia and cognitive impairment,
strategies are needed to slow age-related decline and reduce disease-related cognitive …

Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging

JE Ahlskog, YE Geda, NR Graff-Radford… - Mayo clinic …, 2011 - Elsevier
A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise,
may attenuate cognitive impairment and reduce dementia risk. We used PubMed (keywords …

A meta-analysis of cytokines in Alzheimer's disease

W Swardfager, K Lanctôt, L Rothenburg, A Wong… - Biological …, 2010 - Elsevier
BACKGROUND: Studies suggest that inflammation is involved in the neurodegenerative
cascade leading to Alzheimer's disease (AD) pathology and symptoms. This study sought to …

The neuropathology of sport

AC McKee, DH Daneshvar, VE Alvarez, TD Stein - Acta neuropathologica, 2014 - Springer
The benefits of regular exercise, physical fitness and sports participation on cardiovascular
and brain health are undeniable. Physical activity reduces the risk for cardiovascular …

Measures of frailty in population-based studies: an overview

K Bouillon, M Kivimaki, M Hamer, S Sabia, EI Fransson… - BMC geriatrics, 2013 - Springer
Background Although research productivity in the field of frailty has risen exponentially in
recent years, there remains a lack of consensus regarding the measurement of this …