UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …

Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …

Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Cross-sectional studies have demonstrated strong associations between physical frailty and
depression. However, the evidence from prospective studies is limited. Here, we analyze …

Background Grip strength is a widely used and well-validated measure of overall health that
is increasingly understood to index risk for psychiatric illness and neurodegeneration in …

Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Background and aims Observational studies have linked elevated blood pressure (BP) to
impaired cognitive function. However, the functional and structural changes in the brain that …

Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …

Background Physical frailty is a state of increased vulnerability to stressors and is associated
with serious health issues. However, how frailty affects and is affected by numerous other …