Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

The upcoming 11th revision of the International Statistical Classification of Diseases and
Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique …

Background Disorders affecting the nervous system are diverse and include
neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions …

Background This review is one of a series on drugs used to treat chronic neuropathic pain.
Estimates of the population prevalence of chronic pain with neuropathic components range …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and
nociceptive responses to non-noxious stimuli (allodynia). The conditions and the …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Background Gabapentin is commonly used to treat neuropathic pain (pain due to nerve
damage). This review updates a review published in 2014, and previous reviews published …