Schizophrenia: Antipsychotics and drug development
The introduction of chlorpromazine and the work that ensued provided the foundation to
reposition schizophrenia as a biological illness. The present paper follows the evolution of …
reposition schizophrenia as a biological illness. The present paper follows the evolution of …
Molecular fMRI of neurochemical signaling
Magnetic resonance imaging (MRI) is the most widely applied technique for brain-wide
measurement of neural function in humans and animals. In conventional functional MRI …
measurement of neural function in humans and animals. In conventional functional MRI …
No basal or drug‐induced sex differences in striatal dopaminergic levels: A cluster and meta‐analysis of rat microdialysis studies
L Egenrieder, E Mitricheva, R Spanagel… - Journal of …, 2020 - Wiley Online Library
Sex differences in behavioural patterns of drug abuse and dependence have been
hypothesized to be a consequence of sexual dimorphisms in brain pathways, particularly …
hypothesized to be a consequence of sexual dimorphisms in brain pathways, particularly …
[HTML][HTML] Common changes in rat cortical gene expression after chronic treatment with chlorpromazine and haloperidol may be related to their antipsychotic efficacy
B Dean, E Scarr - Neuroscience Applied, 2023 - Elsevier
It has been postulated that common molecular changes resulting from treatment with
antipsychotic drugs are involved in their therapeutic mechanisms of action. There are …
antipsychotic drugs are involved in their therapeutic mechanisms of action. There are …
[HTML][HTML] Gestational iron supplementation reverses depressive-like behavior in post-partum Sprague Dawley rats: Evidence from behavioral and neurohistological …
Background Postpartum depression is a mood disorder that affects about 9–20% of women
after child birth. Reports suggest that gestational iron deficiency can cause a deficit in …
after child birth. Reports suggest that gestational iron deficiency can cause a deficit in …
[HTML][HTML] Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats
Rats have been used as animal models for human diseases for more than a century, yet a
systematic understanding of basal biobehavioral phenotypes of laboratory rats is still …
systematic understanding of basal biobehavioral phenotypes of laboratory rats is still …
The current status and work of three rs centres and platforms in Europe
W Neuhaus, B Reininger-Gutmann… - Alternatives to …, 2022 - journals.sagepub.com
The adoption of Directive 2010/63/EU on the protection of animals used for scientific
purposes has given a major push to the formation of Three Rs initiatives in the form of …
purposes has given a major push to the formation of Three Rs initiatives in the form of …
Developmental trajectory of episodic-like memory in rats
Introduction Episodic memory formation requires the binding of multiple associations to a
coherent episodic representation, with rich detail of times, places, and contextual …
coherent episodic representation, with rich detail of times, places, and contextual …
Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer's Disease
C Behl - Alzheimer's Disease Research: What Has Guided …, 2023 - Springer
Cholinergic neurotransmission is essential for cognitive processes in the human brain and
was found to be disturbed in Alzheimer's disease. Since Alzheimer's disease is associated …
was found to be disturbed in Alzheimer's disease. Since Alzheimer's disease is associated …
Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs: A meta-and cluster analysis of preclinical studies
LH Mervin, E Mitricheva… - Journal of Cerebral …, 2021 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) is an extensively used method for the
investigation of normal and pathological brain function. In particular, fMRI has been used to …
investigation of normal and pathological brain function. In particular, fMRI has been used to …