Drug repurposing for antimicrobial discovery
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …
along with significant agricultural crop loss caused by various fungal species, has resulted in …
Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition
In recent years, the demand for novel antifungal therapies has increased several-folds due
to its potential to treat severe biofilm-associated infections. Biofilms are made by the sessile …
to its potential to treat severe biofilm-associated infections. Biofilms are made by the sessile …
Current antimycotics, new prospects, and future approaches to antifungal therapy
G Wall, JL Lopez-Ribot - Antibiotics, 2020 - mdpi.com
Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
Drug repositioning and repurposing: terminology and definitions in literature
J Langedijk, AK Mantel-Teeuwisse, DS Slijkerman… - Drug discovery today, 2015 - Elsevier
Highlights•Drug repositioning and similar terms have been a trending topic since
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …
Antifungal therapy with an emphasis on biofilms
Highlights•Fungal infections affect an expanding population of immunosuppressed
patients.•The current arsenal of antifungal drugs is exceedingly limited.•Toxicity problems …
patients.•The current arsenal of antifungal drugs is exceedingly limited.•Toxicity problems …
Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs
Introduction: Targeting pathogenetic mechanisms, rather than essential processes,
represents a very attractive alternative for the development of new antibiotics. This may be …
represents a very attractive alternative for the development of new antibiotics. This may be …
Screening a repurposing library for inhibitors of multidrug-resistant Candida auris identifies ebselen as a repositionable candidate for antifungal drug development
Since its original isolation in 2009, Candida auris has spread across the globe as a
causative agent of invasive candidiasis. C. auris is typically intrinsically resistant to …
causative agent of invasive candidiasis. C. auris is typically intrinsically resistant to …
Tackling fungal resistance by biofilm inhibitors
S Wu, Y Wang, N Liu, G Dong… - Journal of Medicinal …, 2017 - ACS Publications
The high incidence and mortality of invasive fungal infections and serious drug resistance
have become a global public health issue. The ability of fungal cells to form biofilms is an …
have become a global public health issue. The ability of fungal cells to form biofilms is an …
[HTML][HTML] Antifungal therapy of Candida biofilms: Past, present and future
Virtually all Candida species linked to clinical candidiasis are capable of forming highly
resistant biofilms on different types of surfaces, which poses an additional significant threat …
resistant biofilms on different types of surfaces, which poses an additional significant threat …